Objectives. To characterize tumour baseline blood flow (BF) in two lung cancer subtypes, adenocarcinoma (AC) and squamous\ncell carcinoma (SCC), also investigating those â??borderlineâ? cases whose perfusion value is closer to the group mean of the other\nhistotype. Materials and Methods. 26 patients (age range 36-81 years) with primary Non-Small Cell Lung Cancer (NSCLC),\nsubdivided into 19 AC and 7 SCC, were enrolled in this study and underwent a CT perfusion, at diagnosis. BF values were computed\naccording to the maximum-slope method and unreliable values (e.g., arising fromartefacts or vessels) were automatically removed.\nThe one-tail Welchâ??s t-test (.....) was employed for statistical assessment. Results. At diagnosis, mean BF values (...) of AC group (.....) are significantly greater than those of SCC subtype (....) (....) However, two central SCCs undergoing artefacts from vena cava and pulmonary artery have an artificially increased mean BF.\nConclusions. The different hemodynamic behaviour of AC and SCC should be considered as a biomarker supporting treatment\nplanning to select the patients, mainly with AC, that would most benefit from antiangiogenic therapies. The significance of results\nwas achieved by automatically detecting and excluding artefactual BF values.
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